The Project

Marie Curie

Workplan

The TRANSACT workplan consists of 7 Workpackages:

  • WP1 Management

  • WP2 Training

  • WP3-WP6 Research

  • WP7 Dissemination and Outreach

 WP1 Management

The main goals of the Project Management are:

  • Financial management

  • Recruitment strategy

  • Gender Balance

  • Project monitoring

  • Networking

 WP 2 Training

The main goal  of this Workpackage is to train young researchers in an evolving and challenging branch of medical imaging technology (MR spectroscopy).

The required multidisciplinary education is difficult to achieve through existing training at individual institutions. Therefore, there is a need for collaborative upscale research and training at European and international level.

TRANSACT will address this challenge through a scientific training programme combining topics from many different disciplines linked to MRS, including quantum mechanics, spin physics, radiology, biomedical signal and image processing, computational mathematics, and computer science. The ESRs will acquire a deep knowledge of both theoretical and practical aspects in these fields, thus growing as scientists and preparing themselves to follow careers in academic research, R&D in industry, or in a clinical environment.

Additionally, the training programme will promote international, interdisciplinary and inter-sectoral mobility through secondments and participation at network-wide or global events.

The training programme contains specific scientific and transferable skills, and it is achieved through both local supervision and network-wide activities. The modalities of training are:

  • Individual research projects
  • Network-wide training activities (workshops, courses, meetings)
  • Local training activities: courses offered by the doctoral schools, events in local research groups. Fellows from other partners (during secondments) may follow such local courses.
  • External (international) training activities.

WP 3 Research (RP1 MRS quality)

Design and implementation of spectral quality scores and of robust, automated and efficient MRS(I) data simulation and processing

Objectives: definition of spectral quality scores; extended functionality of the “virtual scanner”; robustness and automation of the software package jMRUI.

This workpackage consists of the following Individual Research Projects (IRP):

  • IRP 1.1 Definition of spectral quality scores and use of reference signals
  • IRP 1.2 Virtual scanner – computer simulation for spectroscopic quantitation, pulse sequence optimization and data analysis development
  • IRP 1.3 Modification of jMRUI, software for processing and analysis of in vivo MR data, towards standardization, automation and quality assurance for clinical practice

WP 4 Research (RP1 MRS quality)

Optimisation, standardization and in vivo validation of protocols, quality criteria and quantitation

Objectives: optimisation of single-voxel examination protocol on 3 Tesla scanners; optimised MRSI acquisition, post-processing and automatic tumour analysis; real-time correcting for subject movement during MRSI acquisition; predicting outcome of glioma therapy in clinical and preclinical studies.


This workpackage consists of the following Individual Research Projects (IRP):

  • IRP 2.1 Optimization and standardization of single voxel protocol and quantitation
  • IRP 2.2 Combined acquisition & post-processing strategies for optimized MRSI data Acquisition
  • IRP 2.3 Echo-planar-based spectroscopic imaging with online motion correction
  • IRP 2.4 From preclinical to clinical MRS-based classification for glioma therapy assessment

 WP 5 Research (RP2 MRS in multi-modal fusion)

Design and implementation of multi-modal MR data quantitation and classification

Objectives: combining MRI and advanced MRS data processing in one application for the progression/treatment-evaluation of malignant glioma in humans; up-sampling of MRSI images by combining MRSI and anatomical MRIs; multi-modal (un)supervised classifiers for brain tumour diagnosis and prognosis; spectral classification methods as meta-plug-ins for jMRUI.

This workpackage consists of the following Individual Research Projects (IRP):

  • IRP 3.1 Brain Tumour MRS / MRI Analyzer
  • IRP 3.2 Combining anatomical and spectral information to enhance MRSI resolution and quantitation
  • IRP 3.3 Classifiers for tumour tissue differentiation based on multi-modal MR data
  • IRP 3.4 decision support system and spectral classification tool meta-plugins for the jMRUI Platform

WP 6 Research (RP2 MRS in multi-modal fusion)

Validation of multi-modal MR methods in clinical applications

Objectives: integration of MRS data with structural information from multi-modal MR data with application to monitoring neurological disorders; analysis of correlations between micro-structural changes and metabolic alterations in the follow-up of multiple sclerosis patients by multi-modal MR methods, including MRSI and diffusion tensor imaging.

This workpackage consists of the following Individual Research Projects (IRP):

  • IRP 4.1 MRS as part of a comprehensive neuroimaging assessment
  • IRP 4.2 Multi-modal follow-up of Multiple Sclerosis patients

 WP 7 Dissemination and Outreach

Dissemination

  • Publishing papers in high impact journals and make some scientific publications available in open access Normal 0 21 false false false MicrosoftInternetExplorer4
  • Promoting jMRUI software and the TRANSACT network at conferences, user meetings, on the web, and through the organization of training courses
  • Participation of fellows as Marie Curie ambassadors for science and technology at (national-level) science fairs
  • Knowledge sharing, dissemination and open access
  • The TRANSACT demonstrator
  • TRANSACT website – tool for dissemination, collaboration, and progress reporting


Outreach:

The TRANSACT will organize and encourage outreach activities where the recruited ESRs will act as presenter, guide, or creator of (multimedia) dissemination material. A particular type of activities that we envisage is participation with the TRANSACT demonstrator at local, national or European-level science events